Functional considerations between flap and non-flap reconstruction in oral tongue cancer: A systematic review.

This systematic review aims to provide insight into the ideal reconstructive approach of the oral tongue in oral tongue cancer (OTC) by investigating the relationship between functional outcomes and the extent of tongue resection. A structured search was performed in Ovid MEDLINE, EMBASE, and Web of Science. Studies comparing patient-reported and objective measurements of the oral tongue function between flap vs. non-flap reconstruction were included. Functional outcomes of interest were speech production, deglutition efficiency, tongue mobility, overall quality of life, and postoperative complications. A total of nine studies were retrieved and critically appraised. Patients with 20 % or less of oral tongue resected had superior swallowing efficiency and speech intelligibility with a non-flap reconstruction while patients with a tongue defect of 40-50 % self-reported or demonstrated better swallowing function with a flap repair. The data in intermediate tongue defects (20-40 % tongue resected) was inconclusive, with several studies reporting comparable functional outcomes between approaches. A longitudinal multi-institutional prospective study that rigidly controls the extent of tongue resected and subsites involved is needed to determine the percentage of tongue resected at which a flap reconstruction yields a superior functional result in OTC.

Risk assessment of arsenic and other metals via atmospheric particles, and effects of atmospheric exposure and other demographic factors on their accumulations in human scalp hair in urban area of Guangzhou, China.

Eighty-eight scalp hair samples were collected from Guangzhou (GZ) urban population (15-65 years) to investigate the accumulation of As and other metals (Cr, Mn, Ni, Cu, Zn, Cd, Sn, Sb, Hg and Pb). Demographic information, including body weight, height, age, gender, habits of smoking and drinking, types of drinking water, duration of stay in GZ, days of stay in GZ per year (days/year), and hours spent in indoor environment per day (h/day), were also recorded during hair sampling to refine the uncertainty of risk assessment derived from exposures to elements via dust and airborne particles. No significant non-carcinogenic risk was found. However, the cancer risks of Cr and As for both ingestion and inhalation exceeded the most tolerable regulated level (1.0×10(-6)). The environmental exposures to urban dust and airborne particles were observed significantly correlated to accumulations of Cd (R=0.306, p=0.005) and Ni (R=0.333, p=0.002) in scalp hair. Furthermore, the hair burden of elements was also significantly (p<0.05) dependent on gender (Mn, Ni, Zn, As, Sn and Hg), age (Cr, As, Cd and Hg), duration of stay in GZ (Hg) as well as nutritional and physical status, reflected by BMI and BSA (Cr, Ni, Cd, Sb and Hg). Nutritional and physical status was observed as the exclusive important factor influencing As speciation in human scalp hair. However, habits of smoking and alcohol drinking as well as types of drinking water were not identified as the significant influencing factors on any element (p>0.05).

Arsenic speciation in total contents and bioaccessible fractions in atmospheric particles related to human intakes.

Speciation of inorganic trivalent arsenicals (iAs(III)), inorganic pentavalent arsenicals (iAs(V)), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in total arsenic (As) content and its bioaccessible fractions contained in road dust, household air-conditioning (AC) filter dust and PM2.5 was investigated. Inorganic As, especially iAs(V), was observed as the dominant species. Physiologically based extraction test (PBET), an in-vitro gastrointestinal method, was used to estimate the oral As bioaccessibility in coarse particles and the species present in the oral bioaccessible fraction. A composite lung simulating serum was used to mimic the pulmonary condition to extract the respiratory bioaccessible As and its species in PM2.5. Reduction of iAs(V) to iAs(III) occurred in both in-vitro gastrointestinal and lung simulating extraction models. The inorganic As species was the exclusive species for absorption through ingestion and inhalation of atmospheric particles, which was an important exposure route to inorganic As, in addition to drinking water and food consumption.

Oral bioaccessibility of polycyclic aromatic hydrocarbons (PAHs) through fish consumption, based on an in vitro digestion model.

An in vitro gastrointestinal digestion model was used to evaluate bioaccessibility of PAHs in 20 fish species collected from Hong Kong markets. The average bioaccessibilities of PAHs were 24.3 and 31.1%, respectively, in gastric and intestinal conditions. When bioaccessibility was taken into consideration, the values of potency equivalent concentrations (PEC) decreased from 0.53 to 0.18 ng g(-1) for freshwater fish and from 1.43 to 0.35 ng g(-1) for marine fish. This indicated that bioaccessibility should be taken into account for health risk assessment with regard to PAH contamination in fish. The relative accumulation ratios (R(nn)) of PAH congeners were significantly correlated with their physicochemical parameters and their corresponding concentrations reported in subcutaneous fats of Hong Kong residents. The data suggest that R(nn) values calculated in the present study could effectively reflect the accumulations of PAHs in the human body.